/* DeNovoVHH-DB — dashboard design system (navy→teal gradient, academic) */
:root{
  --navy:#153050; --navy-2:#1b4b7a; --ink:#1f2d3d; --muted:#5b6b7b;
  --teal:#0e7c86; --teal-2:#0a5f68; --accent:#2f6fb0; --line:#e2e8ef;
  --bg:#ffffff; --bg-soft:#f6f8fb; --bg-panel:#fbfcfe;
  --green:#1f9254; --green-bg:#e6f4ec; --blue:#2f6fb0; --blue-bg:#e7f0f9;
  --gray:#6b7785; --gray-bg:#eef1f4; --amber:#a86a15; --amber-bg:#fbf1de;
  --purple:#6b3fa0; --purple-bg:#efe8f8; --red:#b3261e;
  --g1:#14263c; --g2:#1c4f6e; --g3:#2f7d5c;   /* gradient stops: navy → teal → green */
  --radius:7px; --shadow:0 1px 3px rgba(20,40,70,.08),0 1px 2px rgba(20,40,70,.06);
  --shadow-lg:0 6px 20px rgba(20,40,70,.10);
}
*{box-sizing:border-box}
body{margin:0;font-family:-apple-system,BlinkMacSystemFont,"Segoe UI",Roboto,Helvetica,Arial,sans-serif;
  color:var(--ink);background:var(--bg-soft);font-size:14.5px;line-height:1.5}
a{color:var(--accent);text-decoration:none}
a:hover{text-decoration:underline}
.container{max-width:1280px;margin:0 auto;padding:0 22px}
.mono{font-family:"SF Mono",ui-monospace,"Cascadia Code",Menlo,Consolas,monospace}

/* ---------- Header (gradient) ---------- */
header.site{background:linear-gradient(90deg,var(--g1) 0%,var(--g2) 52%,var(--g3) 100%);
  position:sticky;top:0;z-index:60;box-shadow:0 2px 10px rgba(10,25,45,.25)}
.topnav{display:flex;align-items:center;gap:18px;padding:11px 0}
.brand{display:flex;align-items:center;gap:12px;color:#fff}
.brand:hover{text-decoration:none}
.brand .logo{width:40px;height:40px;flex:none}
.brand .name{font-size:21px;font-weight:800;color:#fff;letter-spacing:-.3px;line-height:1.02;display:block}
.brand .sub{font-size:11px;color:#bfe0e8;letter-spacing:.02em;margin-top:3px;display:block}
.topnav .spacer{flex:1}
.uni-logo{background:#fff;border-radius:8px;padding:6px 9px;display:flex;align-items:center;height:42px}
.uni-logo img{height:30px;display:block}

/* dropdown nav */
.menu{display:flex;align-items:center;gap:3px}
.menu>li{list-style:none;position:relative}
.menu>li>a{display:inline-flex;align-items:center;gap:5px;color:#eaf3f6;padding:9px 13px;border-radius:6px;
  font-size:14px;font-weight:600;cursor:pointer}
.menu>li>a:hover,.menu>li:hover>a,.menu>li:focus-within>a{background:rgba(255,255,255,.14);color:#fff;text-decoration:none}
.menu>li>a.active{background:rgba(255,255,255,.18);color:#fff}
.menu .caret{font-size:9px;opacity:.8;margin-top:1px}
.menu .drop{position:absolute;top:100%;left:0;min-width:220px;background:#fff;border:1px solid var(--line);
  border-radius:9px;box-shadow:var(--shadow-lg);padding:6px;opacity:0;visibility:hidden;transform:translateY(6px);
  transition:opacity .13s,transform .13s;z-index:70}
.menu>li:hover .drop,.menu>li:focus-within .drop{opacity:1;visibility:visible;transform:translateY(4px)}
.menu .drop a{display:block;padding:8px 12px;border-radius:6px;color:var(--ink);font-size:13.5px;font-weight:500}
.menu .drop a:hover{background:var(--bg-soft);text-decoration:none;color:var(--navy)}
.menu .drop .hint{display:block;font-size:11.5px;color:var(--muted);font-weight:400;margin-top:1px}
.menu .drop .sep{height:1px;background:var(--line);margin:5px 8px}

/* ---------- Masthead (home hero band, same gradient) ---------- */
.masthead{background:linear-gradient(90deg,var(--g1) 0%,var(--g2) 52%,var(--g3) 100%);
  color:#fff;margin-top:-1px}
.masthead .container{padding-top:26px;padding-bottom:30px}
.masthead h1{font-size:40px;font-weight:800;color:#fff;letter-spacing:-.6px;margin:0}
.masthead .tag{font-size:16px;color:#d7ebf1;margin-top:6px;font-weight:400}
.masthead .kicker{font-size:12px;letter-spacing:.16em;text-transform:uppercase;color:#8fd0c6;font-weight:700}
/* tabbed search */
.hsearch{background:rgba(255,255,255,.10);border:1px solid rgba(255,255,255,.22);border-radius:12px;
  padding:8px;margin-top:22px;backdrop-filter:blur(2px)}
.htabs{display:flex;gap:4px;flex-wrap:wrap;padding:2px 2px 8px}
.htabs a{color:#d7ebf1;font-size:13px;font-weight:600;padding:6px 13px;border-radius:7px}
.htabs a:hover{background:rgba(255,255,255,.14);text-decoration:none;color:#fff}
.htabs a.active{background:#fff;color:var(--navy)}
.hsearch form{display:flex;gap:8px}
.hsearch input[type=text]{flex:1;border:0;border-radius:8px;padding:12px 15px;font-size:14.5px;outline:none}
.hsearch button{border:0;background:var(--teal);color:#fff;font-weight:700;font-size:14px;
  padding:12px 22px;border-radius:8px;cursor:pointer}
.hsearch button:hover{background:var(--teal-2)}
.hsearch .helper{color:#bfe0e8;font-size:11.5px;padding:6px 4px 2px}

/* ---------- Action cards ---------- */
.actioncards{display:grid;grid-template-columns:repeat(3,1fr);gap:16px;margin:-26px 0 22px;position:relative;z-index:5}
.actioncard{background:#fff;border:1px solid var(--line);border-radius:11px;box-shadow:var(--shadow-lg);
  padding:18px 20px}
.actioncard h3{margin:0 0 4px;font-size:16px;color:var(--navy);text-align:center}
.actioncard .row3{display:flex;justify-content:space-around;gap:8px;margin-top:12px}
.actioncard .row3 a{display:flex;flex-direction:column;align-items:center;gap:7px;font-size:12px;
  color:var(--muted);font-weight:600;text-align:center;flex:1;padding:8px 4px;border-radius:8px}
.actioncard .row3 a:hover{background:var(--bg-soft);text-decoration:none;color:var(--navy)}
.actioncard .row3 svg{width:30px;height:30px;color:var(--teal)}

/* ---------- Dashboard ---------- */
.dashboard{display:flex;gap:20px;align-items:flex-start;margin-top:6px}
.dash-main{flex:1;min-width:0;display:flex;flex-wrap:wrap;gap:16px;align-content:flex-start}
.dash-main>.tile{flex:1 1 300px;min-width:0}
.dash-main>.tile.wide{flex-basis:100%}
.dash-side{width:320px;flex:none;display:flex;flex-direction:column;gap:16px}
.tile{background:#fff;border:1px solid var(--line);border-radius:11px;box-shadow:var(--shadow);padding:16px 18px}
.tile h3{margin:0 0 12px;font-size:14.5px;color:var(--navy);display:flex;justify-content:space-between;align-items:center}
.tile h3 .more{font-size:12px;font-weight:500}
.sidepanel{background:#fff;border:1px solid var(--line);border-radius:11px;box-shadow:var(--shadow);overflow:hidden}
.sidepanel h3{margin:0;background:var(--bg-soft);border-bottom:1px solid var(--line);
  padding:11px 16px;font-size:14px;color:var(--navy)}
.sidepanel .body{padding:14px 16px}
.statlist{display:flex;flex-direction:column}
.statlist .r{display:flex;justify-content:space-between;align-items:baseline;padding:7px 0;border-bottom:1px dashed var(--line)}
.statlist .r:last-child{border-bottom:0}
.statlist .r .v{font-weight:800;color:var(--navy);font-size:15px}
.statlist .r .k{font-size:13px;color:var(--muted)}

/* donut */
.donut-wrap{display:flex;align-items:center;gap:16px;flex-wrap:wrap}
.donut{width:130px;height:130px;flex:none}
.legend{font-size:12.5px;display:flex;flex-direction:column;gap:5px;flex:1;min-width:130px}
.legend .li{display:flex;align-items:center;gap:8px}
.legend .sw{width:11px;height:11px;border-radius:3px;flex:none}
.legend .li .n{margin-left:auto;color:var(--muted);font-variant-numeric:tabular-nums}

/* horizontal bars */
.hbars{display:flex;flex-direction:column;gap:9px}
.hbars .b{display:grid;grid-template-columns:110px 1fr auto;gap:9px;align-items:center;font-size:12.5px}
.hbars .b .lab{color:var(--ink);white-space:nowrap;overflow:hidden;text-overflow:ellipsis}
.hbars .b .track{background:var(--bg-soft);border-radius:5px;height:14px;overflow:hidden}
.hbars .b .track>span{display:block;height:100%;background:linear-gradient(90deg,var(--teal),var(--green));border-radius:5px}
.hbars .b .val{color:var(--muted);font-variant-numeric:tabular-nums;min-width:38px;text-align:right}

/* featured record */
.feat{font-size:13px}
.feat .fid{font-weight:800;color:var(--navy);font-size:15px}
.feat .frow{display:flex;justify-content:space-between;padding:4px 0;border-bottom:1px dashed var(--line)}
.feat .frow:last-child{border-bottom:0}
.feat .frow .k{color:var(--muted)}

/* ---------- Profile card (About) ---------- */
.profile{display:grid;grid-template-columns:170px 1fr auto;gap:22px;align-items:center}
.profile img.photo{width:170px;height:200px;object-fit:cover;border-radius:10px;border:1px solid var(--line);box-shadow:var(--shadow)}
.profile .who .nm{font-size:20px;font-weight:800;color:var(--navy)}
.profile .who .role{font-size:14px;color:var(--teal-2);font-weight:600;margin-top:2px}
.profile .who .aff{font-size:13.5px;color:var(--muted);line-height:1.7;margin-top:8px}
.profile .who a{font-weight:600}
.profile .uni img{height:96px;display:block}
@media(max-width:760px){.profile{grid-template-columns:1fr;text-align:center}.profile img.photo{margin:0 auto}}

/* ---------- Layout ---------- */
main{padding:26px 0 60px;min-height:60vh}
main .container>.breadcrumb:first-child{margin-top:0}
.breadcrumb{font-size:12.5px;color:var(--muted);margin-bottom:14px}
.breadcrumb a{color:var(--muted)}
h1{font-size:26px;color:var(--navy);margin:.1em 0 .3em;font-weight:800;letter-spacing:-.3px}
h2{font-size:18px;color:var(--navy);margin:1.4em 0 .6em;font-weight:700}
h3{font-size:15px;color:var(--navy);margin:1.1em 0 .5em;font-weight:700}
.lead{color:var(--muted);font-size:15px;max-width:70ch}
.grid{display:grid;gap:18px}
.row{display:flex;gap:18px;flex-wrap:wrap}
.col{flex:1;min-width:0}

/* ---------- Buttons ---------- */
.btn{display:inline-flex;align-items:center;gap:7px;background:var(--navy);color:#fff;
  border:1px solid var(--navy);padding:9px 17px;border-radius:7px;font-size:13.5px;
  font-weight:600;cursor:pointer}
.btn:hover{background:var(--navy-2);text-decoration:none;color:#fff}
.btn.outline{background:#fff;color:var(--navy)}
.btn.outline:hover{background:var(--bg-soft)}
.btn.teal{background:var(--teal);border-color:var(--teal)}
.btn.teal:hover{background:var(--teal-2)}
.btn.sm{padding:5px 11px;font-size:12.5px}

/* ---------- Stat tiles (statistics page) ---------- */
.stats{display:grid;grid-template-columns:repeat(6,1fr);gap:14px;margin:18px 0 8px}
.stat{background:#fff;border:1px solid var(--line);border-radius:9px;padding:16px 14px;
  text-align:center;box-shadow:var(--shadow)}
.stat .num{font-size:26px;font-weight:800;color:var(--navy);line-height:1}
.stat .lbl{font-size:11.5px;color:var(--muted);margin-top:6px}
.stat .ic{color:var(--teal);font-size:18px;margin-bottom:4px}

/* ---------- Cards / panels ---------- */
.panel{background:#fff;border:1px solid var(--line);border-radius:9px;padding:18px 20px;
  box-shadow:var(--shadow);margin-bottom:18px}
.panel h2:first-child,.panel h3:first-child{margin-top:0}
.card-grid{display:grid;grid-template-columns:repeat(auto-fill,minmax(280px,1fr));gap:14px}
.vhh-card{border:1px solid var(--line);border-radius:8px;padding:13px 15px;background:#fff}
.vhh-card .id{font-weight:700;color:var(--navy)}
.vhh-card .meta{font-size:12.5px;color:var(--muted);margin-top:3px}

/* ---------- Tables ---------- */
table.data{width:100%;border-collapse:collapse;font-size:13px}
table.data th{background:var(--bg-soft);text-align:left;padding:9px 11px;font-weight:600;
  color:var(--navy);border-bottom:2px solid var(--line);white-space:nowrap}
table.data td{padding:8px 11px;border-bottom:1px solid var(--line);vertical-align:top}
table.data tr:hover td{background:#fafcfe}
table.kv{width:100%;border-collapse:collapse;font-size:13.5px}
table.kv th{text-align:left;padding:7px 12px 7px 0;color:var(--muted);font-weight:500;
  width:200px;vertical-align:top;white-space:nowrap}
table.kv td{padding:7px 0;border-bottom:1px solid var(--line);vertical-align:top}
table.kv tr:last-child td,table.kv tr:last-child th{border-bottom:0}

/* ---------- Badges ---------- */
.badge{display:inline-block;padding:2px 9px;border-radius:11px;font-size:11.5px;font-weight:600;
  line-height:1.6;white-space:nowrap}
.b-green{background:var(--green-bg);color:var(--green)}
.b-blue{background:var(--blue-bg);color:var(--blue)}
.b-gray{background:var(--gray-bg);color:var(--gray)}
.b-amber{background:var(--amber-bg);color:var(--amber)}
.b-purple{background:var(--purple-bg);color:var(--purple)}
.b-teal{background:#e2f1f2;color:var(--teal-2)}
.ev{display:inline-block;font-family:ui-monospace,monospace;font-size:11px;font-weight:700;
  padding:1px 6px;border-radius:4px;background:var(--navy);color:#fff;margin-right:3px}
.nr{color:#9aa7b4;font-style:italic}

/* ---------- Tabs ---------- */
.tabs{display:flex;gap:2px;border-bottom:2px solid var(--line);margin:18px 0 0;flex-wrap:wrap}
.tabs a,.tabs button{padding:10px 15px;font-size:13.5px;font-weight:600;color:var(--muted);
  border:0;background:none;cursor:pointer;border-bottom:2px solid transparent;margin-bottom:-2px}
.tabs a.active,.tabs button.active{color:var(--navy);border-bottom-color:var(--teal)}
.tabpane{display:none;padding-top:18px}
.tabpane.active{display:block}

/* ---------- Filter sidebar ---------- */
.layout-2{display:grid;grid-template-columns:250px 1fr;gap:24px;align-items:start}
.filters{background:var(--bg-panel);border:1px solid var(--line);border-radius:9px;padding:16px}
.filters h3{margin-top:0;font-size:13px;text-transform:uppercase;letter-spacing:.04em;color:var(--muted)}
.filters .fgroup{margin-bottom:16px}
.filters label{display:block;font-size:13px;padding:3px 0;cursor:pointer}
.filters select,.filters input{width:100%;padding:6px 8px;border:1px solid var(--line);
  border-radius:6px;font-size:13px;margin-top:3px}

/* ---------- Sequence / CDR ---------- */
.fasta{background:#0f2440;color:#d7e6f5;border-radius:8px;padding:14px 16px;font-family:ui-monospace,monospace;
  font-size:12.5px;line-height:1.7;overflow-x:auto;white-space:pre-wrap;word-break:break-all}
.cdrstrip{display:flex;font-family:ui-monospace,monospace;font-size:12px;border-radius:6px;overflow:hidden;
  border:1px solid var(--line);flex-wrap:wrap}
.cdrstrip .seg{padding:8px 6px}
.seg-fr{background:#eef2f6;color:#42586c}
.seg-cdr1{background:#fde9d0;color:#8a5316}
.seg-cdr2{background:#d9f0e4;color:#1a6b42}
.seg-cdr3{background:#f6d9de;color:#95323f}
.seglabel{font-size:10px;font-weight:700;display:block;opacity:.7;text-transform:uppercase}

/* ---------- Viewer ---------- */
#molstar,.viewer{width:100%;height:460px;border:1px solid var(--line);border-radius:9px;
  position:relative;background:var(--bg-soft)}
.viewer-controls{display:flex;flex-direction:column;gap:7px;font-size:13px}
.viewer-controls label{display:flex;align-items:center;gap:7px}

/* ---------- Provenance timeline ---------- */
.prov{border-left:2px solid var(--line);padding-left:16px;margin-left:6px}
.prov .ev-item{position:relative;padding:8px 0}
.prov .ev-item::before{content:"";position:absolute;left:-22px;top:14px;width:9px;height:9px;
  border-radius:50%;background:var(--teal);border:2px solid #fff}
.prov .fld{font-weight:600;color:var(--navy)}
.prov .src{font-size:12px;color:var(--muted)}

/* ---------- Pagination ---------- */
.pager{display:flex;gap:5px;align-items:center;justify-content:center;margin:22px 0;flex-wrap:wrap}
.pager a,.pager span{padding:6px 11px;border:1px solid var(--line);border-radius:6px;font-size:13px;color:var(--ink)}
.pager a:hover{background:var(--bg-soft);text-decoration:none}
.pager .cur{background:var(--navy);color:#fff;border-color:var(--navy)}
.pager .disabled{color:#b8c2cc}

/* ---------- Misc ---------- */
.pill-row{display:flex;gap:6px;flex-wrap:wrap;align-items:center}
.note{background:var(--bg-soft);border-left:3px solid var(--teal);padding:10px 14px;border-radius:6px;
  font-size:13px;color:var(--muted)}
.citation{background:var(--bg-soft);border:1px solid var(--line);border-radius:7px;padding:12px 14px;font-size:13px}
.citation .j{font-style:italic;color:var(--muted)}
footer.site{border-top:3px solid var(--teal);background:var(--navy);padding:26px 0 22px;font-size:12.5px;color:#b9cad8}
footer.site a{color:#cfe0ec}
footer.site .name{color:#fff}
footer.site b{color:#eaf3f6}
.foot-grid{display:grid;grid-template-columns:2fr 1fr 1fr 1fr;gap:24px}
.footbar{border-top:1px solid rgba(255,255,255,.12);margin-top:20px;padding-top:14px;
  display:flex;justify-content:space-between;gap:14px;flex-wrap:wrap;color:#93a8ba}
.footbar a{margin:0 8px}
.kpi{display:flex;gap:22px;flex-wrap:wrap}
.kpi .k{font-size:12px;color:var(--muted)}
.kpi .k b{display:block;font-size:19px;color:var(--navy)}
.bar{height:9px;background:var(--bg-soft);border-radius:5px;overflow:hidden}
.bar>span{display:block;height:100%;background:var(--teal)}
@media(max-width:980px){
  .dashboard{grid-template-columns:1fr}
  .actioncards{grid-template-columns:1fr}
  .dash-main{grid-template-columns:1fr}
}
@media(max-width:900px){.stats{grid-template-columns:repeat(3,1fr)}.layout-2{grid-template-columns:1fr}
  .foot-grid{grid-template-columns:1fr 1fr}.masthead h1{font-size:30px}}