The De Novo Nanobody Database
A provenance-first catalogue of single-domain antibodies (VHH / nanobodies) spanning the design → validation continuum. Every value is measured, curated, or calculated; absent evidence is shown as “Not reported” and never inferred.
Browse & search 24,780 records →24,780
VHH records
607
Targets
1,300
Structures
984
With measured affinity
1,886
Computational / de novo
428
Linked publications
Evidence quality distribution
| High | 477 | 1.9% |
| Moderate | 933 | 3.8% |
| Low | 23,370 | 94.3% |
| Unresolved | 0 | 0.0% |
Design-method distribution
| unknown | 20,010 |
| natural | 2,755 |
| computational | 1,886 |
| engineering | 91 |
| library | 38 |
Coverage summary
| Attribute | Records | % of DB |
|---|---|---|
| Has experimental structure | 954 | 3.8% |
| Has measured affinity | 984 | 4.0% |
| Computational / de novo | 1,886 | 7.6% |
| Linked to a publication | 860 | 3.5% |
The large “Low quality / Unknown method” fraction is honest: most records derive from repertoire and patent sources that disclose a sequence and target but no independent binding, structure, or design method. They are retained and labelled, not discarded. Publications: 428 distinct linked works; 860 records (3.5%) carry at least one.